노화관련 유전자

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문서 역사
LEF1 — 면역노화 / naive T 세포
  • LEF1 isoforms regulate cellular senescence and aging — PMID 37502913
  • Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways — PMID 40918098

CR1 — 보체 / 알츠하이머 / 노화
  • Effect of complement CR1 on brain amyloid burden during aging (APOE-modified) — PMID 23022416
  • AD-associated CR1 variant confers risk by impacting glial phagocytosis — PMID 40631443
PLD3 — 리소좀 단백질항상성 / 알츠하이머
  • PLD3, neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function — PMID 33830999
  • PLD3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism — PMID 37225734
HNRNPA2B1 — RNA 결합 / 스플라이싱 인자
  • hnRNPA2 regulates β-catenin, overexpressed in prostate cancer — PMID 24823909
  • Alternative splicing in aging and longevity (review) — PMID 31834493
TSPYL2 — 세포 노화 / p53 / DNA 손상 체크포인트
  • TSPYL2 important for G1 checkpoint maintenance upon DNA damage — PMID 21738728
  • TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage — PMID 30050056
  • TSPYL2 is an essential component of the REST/NRSF complex for TGF-β signaling — PMID 25613376
PHF8 — 후성유전 변화 / 노화
  • PHF8 activates rRNA gene transcription via H3K4me3 binding and H3K9me1/2 demethylation — PMID 20208542
  • ELN protects from cellular senescence (PHF8 경로) — PMID 38810421
GNLY — 세포독성 이펙터 확장 / 염증노화
  • GNLY⁺CD8⁺ T cells bridge premature aging and persistent inflammation — PMID 40135938
UFD1 / p97-VCP — 단백질항상성(ERAD)
  • Structural details of Ufd1 binding to p97 in ERAD — PMID 27684549
  • Multisystem proteinopathy mutations in VCP/p97 increase NPLOC4·UFD1L binding — PMID 31623962